Our Reader Score [Total: 0 Average: 0] A dendritic cell-based vaccine targeting HER2 has shown immense promise in a phase-1 clinical trial, as presented at the CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference. HER2 is a type of receptor that is found on the surface of certain cancer cells. Specific hormones and growth factors can bind to
Our Reader Score [Total: 0 Average: 0] Due to a complex and poorly understood mechanism of action, only two medications are currently approved for the treatment of ALS. A multicentre trial was recently carried out in Germany to determine whether rasagiline could improve survival rates in patients with ALS when used with one of these
Our Reader Score [Total: 0 Average: 0] A clinical trial that used sildenafil (Viagra) to treat pregnant women with fetal growth restriction was stopped early due to deaths. Severe early-onset fetal growth restriction is a complication that occurs in about 0.4% of pregnant woman and usually results in the birth of a premature baby, a
Our Reader Score [Total: 0 Average: 0] A recent study in the NEJM describes the outcome of a large clinical trial that compared cardiovascular risks of febuxostat or allopurinol for gout treatment. Gout is a kind of arthritis that occurs due to the formation of urate crystals within the bone joints. Uric acid, a substance
Our Reader Score [Total: 2 Average: 3] A group of researchers in the US modified the existing chemotherapy with humanized antibodies to improve lung cancer survival rates. Lung cancer is the leading cause of death from cancer in Canada. According to The Canadian Cancer Society, about 28,600 Canadians were diagnosed with lung cancer in 2017.
Our Reader Score [Total: 0 Average: 0] A clinical trial of stroke treatments showed that giving three antiplatelet therapy drugs had no benefit over two, and was associated with more bleeding. Recent large-scale clinical trials have shown that starting treatment with two antiplatelet therapy drugs after a stroke, rather than just one, reduces the risk
Our Reader Score [Total: 1 Average: 5] Stem cell clinical trials have the potential to treat and cure genetic and degenerative diseases. However, many recent trials have sacrificed scientific quality and health safety to push quicker clinical trials. Concerned researchers advocating for better clinical trial have proposed new guidelines to deter substandard clinical trials. Stem
Our Reader Score [Total: 1 Average: 2] A recent trial testing the effectiveness of rivaroxaban against aspirin in recurrent stroke prevention was terminated due to risk-benefit concerns. Ischemic strokes occur when blood vessels in the brain become obstructed by blood clots. Approximately 1 in 5 strokes are of the embolic subtype, meaning that the blood
Our Reader Score [Total: 1 Average: 4] Most treatments for multiple sclerosis concentrate on managing symptoms and slowing disease progression. A recent phase-3 trial investigated whether natalizumab is effective in treating secondary progressive multiple sclerosis. Canada has one of the highest incidences of multiple sclerosis (MS) worldwide. An autoimmune disease, MS targets the protective covering
Our Reader Score [Total: 0 Average: 0] The results of a phase-3 trial were recently published comparing the effectiveness of postoperative chemotherapy with chemoradiotherapy for gastric cancer. Gastric carcinoma is a form of cancer that originates in the lining of the stomach. This form of cancer is rare in comparison to other types of cancer.
Our Reader Score [Total: 1 Average: 5] Investigator brochures are key documents in the regulatory approval process before initiating clinical trials. A recent study by German and Canadian researchers investigated just how effective these documents are at enabling accurate risk-benefit assessments. The main purpose of early-phase clinical research is to establish the safety and dosing
Our Reader Score [Total: 4 Average: 3.8] Despite being the gold standard, a recent publication in Annals of Medicine suggests that randomized controlled trials may not be as unbiased as scientists believe. Randomization is an important element of modern clinical trials. It refers to the process of randomly allocating participants to either the experimental or
Our Reader Score [Total: 2 Average: 5] A phase-1b trial funded by Merck and Pfizer combined two drugs to evaluate their effectiveness in treating renal cell carcinoma. Renal cell carcinoma makes up 95% of kidney cancer cases. About 338,000 cases of renal cell carcinoma are detected worldwide every year. Renal cell carcinoma is a form of
Our Reader Score [Total: 0 Average: 0] In a recent study, researchers examined the effects of amobarbital and N-acetylcysteine on post-traumatic osteoarthritis in injured joints. Injury to load-bearing joints such as the knees or ankles can result in posttraumatic osteoarthritis (PTOA), a condition in which the shock-absorbing and friction-reducing joint cartilage breaks down over time.
Our Reader Score [Total: 0 Average: 0] Researchers attempt to identify a therapeutic target that encourages respiratory muscle relaxation to provide asthma relief. Asthma causes respiratory problems, which can manifest as wheezing and chest tightness. It is a common affliction that affects about 10% of the US population. There has been much research focused on
Our Reader Score [Total: 0 Average: 0] Safety is an important aspect of the development of new drugs. Researchers are evaluating the safety and effectiveness of using RNA drugs to deliver instructions to cells to create proteins that are deficient in rare diseases. Messenger ribonucleic acid (mRNA) is an important molecule in the production of
Our Reader Score [Total: 0 Average: 0] A new study has discovered a group of compounds that could give you that suntan glow without having to go out in the sun. If proven safe in clinical trials, you could sport your suntan all year round, and what’s more, they could cut your risk for melanoma,
Our Reader Score [Total: 0 Average: 0] Tuberculosis is a communicable respiratory disease. A group of researchers led by Maeve Lalor conducted a cohort study to determine household transmission of tuberculosis in England by combining epidemiologic and molecular strain typing data. Tuberculosis is a communicable respiratory disease prevalent in some third world countries. In first
Our Reader Score [Total: 0 Average: 0] A group of scientists used an acoustic monitoring program to monitor bee populations at two different sites. The acoustic data was shown to be useful in predicting bee size, the number of bees, and importantly, the amount of bee pollination. Bee populations are on the decline worldwide due
Our Reader Score [Total: 0 Average: 0] A recent study explored the antibacterial effects of modified forms of vancomycin on antibiotic-resistant bacteria. The results suggest C1-aminomethylene vancomycin may be an effective agent against methicillin-resistant Staphylococcus aureus (MRSA) and other antibiotic-resistant bacteria. The ability of bacterial strains to acquire resistance to antibiotics faster than antibacterial therapies
Our Reader Score [Total: 1 Average: 5] Researchers from Duke University in North Carolina produced pathogen-resistant crops without compromising the plant’s yield and fitness. Plants are commonly attacked by microbial, viral or fungal pathogens. Improving crop production involves the applications of pesticides. In recent years, genetically modified pathogen-resistant crops that express a high level of