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A recent pilot study looked at the effects of prazosin in treating suicidal thoughts in PTSD with significant sleep problems.
Suicidal thoughts are common in individuals with post-traumatic stress disorder (PTSD). PTSD is one of the most common mental illnesses these days, and it often includes sleep problems as one of the main symptoms encountered by patients.
PTSD is often associated with insomnia and nightmares. These have been shown to be related to suicidal ideation, as well as suicide. Therefore, the link between PTSD and suicidal thoughts may be mediated by nightmares and sleep problems.
Prazosin is a medication that has been determined to be effective in reducing nightmares in PTSD patients that are not suicidal. In a recent research project published in the Journal of Clinical Psychopharmacology, a group of researchers investigated the potential of this drug to reduce suicide as part of PTSD treatment.
The researchers sorted a group of 20
individuals into either a treatment with prazosin or a placebo group. All the
participants experienced serious warning signs for suicidal ideation as part of
their symptomatology. Furthermore, the participants experienced nightmares and
Prazosin worsened nightmares and did not reduce suicidal thoughts
The study showed that the effects of
nighttime medication were, in fact, a worsening of nightmares and sleep
problems. Suicidal thoughts were also not reduced during this trial.
Mixed results from other trials on this medication have already been reported, suggesting that there indeed might be a negative effect when PTSD patients are treated with this medication. The medication has been in circulation for around a
Extreme nature of PTSD may have affected the results
It may be that the extreme nature of the PTSD in the patients within this sample has affected the results of this study. Nevertheless, no suicide attempts have been reported for this trial.
Another issue reported in this study the large drop-out rates, whereby only six participants have finished suicide. The requirement for weekly visits may have been responsible for these. It is also important to note that the study had a fairly small sample, which may put the results into scrutiny.
Nonetheless, this study raises some red flags with regards to the medication, and further research is needed to verify that this PTSD drug is indeed causing a worsening of symptoms.
Written by Maor Bernshtein
Reference: Mccall, William Vaughn, et
al. “A Pilot, Randomized Clinical Trial of Bedtime Doses of Prazosin Versus
Placebo in Suicidal Posttraumatic Stress Disorder Patients With Nightmares.” Journal
of Clinical Psychopharmacology, 2018, p. 1.,